Download Orthopoxviruses pathogenic for humans by Sergei Nikolaevich Shchelkunov, Svetlana S. Marennikova, PDF

By Sergei Nikolaevich Shchelkunov, Svetlana S. Marennikova, Richard W. Moyer

Orthopoxviruses Pathogenic for people covers these viruses in a position to inflicting illness in guy, together with monkeypox, smallpox, cowpox, and vaccinia. The assurance of every virus is finished, protecting the biology, molecular biology, and ecology of the virus in addition to the scientific and epidemiological elements of those viruses in people and animals. moreover, this quantity highlights advancements in genetic engineering which are paving the way in which for capability healing remedies of those viruses.

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1976), and Gudkov (1980). They found that cotton rats were most sensitive to intracerebral infection. The disease was characterized by adynamia, impaired coordination, and tonic and clonic spasms of back and limb muscles. Doses of 6 log PFU caused death of 80% of animals. 6%; after intraperitoneal infection, 20%. Concurrent experiments with white mice of 5-6 g in weight showed that they were significantly less susceptible than cotton rats. Virological examination of cotton rats at the acme of the disease confirmed the generalized mode of the infection.

In the case of suckling buffaloes, lesions are mainly located in mouth cavity, tongue, and lips. During the outbreaks, dairy and animal care staff usually contracts the disease. , 1997). In 1992-1996, the authors observed children who had no contacts with ill buffaloes yet got infected with buffalopox, which suggested the possibility of infection transmission from their ill parents. Cases of positive seroconversion in persons without any clinical manifestation of the disease were also recorded.

Administration of the virus into rabbits' testes induced orchitis, which led in some cases to testis atrophy. The degree of orchitis development (edema, hyperemia, and sclerosis) after administration of equal doses of various dermal vaccine strains varied from a short inflammation to grave orchitis with necroses and hemorrhagic lesions followed by generalization of the infection and death. The specificity of the process was confirmed in all cases by isolation of the virus from testicular tissue (Mal'tseva, 1965).

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