By Harry L. Ioachim
Now in its Fourth version, this accomplished, functional, and carefully illustrated reference bargains worthwhile advice within the diagnostic interpretation of lymph node biopsies. It offers encyclopedic insurance of the entire a number of nonmalignant lesions, lymphomas, different neoplasms, and metastatic tumors in lymph nodes. The dialogue of every pathologic entity comprises definition, medical syndrome, histopathology, and differential diagnosis.
This version has greater than seven hundred illustrations, together with over six hundred in complete colour. Dr. Ioachim is joined via a brand new co-editor, L. Jeffrey Medeiros, MD, from the collage of Texas MD Anderson melanoma heart. All chapters were generally revised and a brand new bankruptcy on genetics has been added.
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Now in its Fourth version, this complete, useful, and carefully illustrated reference bargains helpful information within the diagnostic interpretation of lymph node biopsies. It offers encyclopedic insurance of the entire a number of nonmalignant lesions, lymphomas, different neoplasms, and metastatic tumors in lymph nodes.
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Additional info for Ioachim’s Lymph Node Pathology
37. Crocker J, Williams M. An enzyme histochemical study of the sinuses of reactive lymph nodes. J Pathol 1984;142:31–38. PA RT T W O DIAGNOSTIC METHODS Lymph nodes are among the organs from which biopsy specimens are most commonly obtained for diagnostic purposes. Their accessibility makes them an easy target for fine needle aspiration and surgical removal. More importantly, because of the role lymph nodes play in retaining and reacting to foreign antigens, any changes therein reflect both regional and systemic disorders.
SUPPORTING FRAMEWORK OR STROMA The lymph node capsule, trabeculae, and a network of reticular cells and reticulin fibers comprise the supporting framework, or stroma. Fibroblasts are the predominant cells of the capsule and trabeculae; however, these structures also include smooth muscle cells, nerves with Schwann cells, and blood vessels with pericytes (1). The reticulin fibers are thin, delicate fibrils of type III collagen about 20 nm in diameter (5). In lymph nodes, they form the main extracellular matrix and maintain the structure by linkage to the fibrous trabeculae, and they are reinforced by fine collagen fibers.
23. 24). The tingible-body macrophages stain with monoclonal antibodies for CD11b, CD35, and CD68. The DRCs stain with monoclonal antibodies for CD21, CD35, C3b, and C3d (34) (Fig. 25). Paracortical Area Those T cells that are the predominant cells of the paracortex are usually small lymphocytes staining with antibodies that recognize pan–T-cell markers such as CD2, CD3, CD5, CD7, CD43, and HLA-DR (Fig. 22). The ratio of CD4+ helper cells to CD8+ suppressor cells is 3:1 (35) (Fig. 24). The IDCs are positive for S100 protein, CD24, and HLA-DR (34).