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This concise, but sensible guide will reduction in assisting the prognosis, remedy, and long term administration of autism, together with behavioral remedies, present scientific trials, and rising pharmaceutical remedies. Autism spectrum sickness (ASD) is a developmental disease characterized by way of disturbance in language, belief, and social talents that is affecting an predicted 1–2 in line with 1,000 humans around the globe (although the quantity is as excessive as 20 in keeping with a thousand within the US). whereas reports have urged a disturbance in neural metabolism in sufferers with advertisements, the precise explanation for the ASD nonetheless is still unknown. In 2013, a unmarried indication of ASD, which united numerous comparable stipulations (ie, classical autism, Asperger’s syndrome, Fragile X Syndrome, Landau-Kleffner Syndrome, Rett syndrome, early life disintegrative ailment, and PDD-NOS), used to be incorporated within the 5th version of the Diagnostic and Statistical handbook of temper issues for the 1st time with the intention to aid extra standardized diagnoses.
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Extra resources for Clinician’s Manual on Autism Spectrum Disorder
2012;51:733-741. 41 Arnold LE, Aman MG, Cook AM, et al. Atomoxetine for hyperactivity in autism spectrum disorders: placebo-controlled crossover pilot trial. J Am Acad Child Adolesc Psychiatry. 2006;45:1196-1205. 42 Stewart ME, Barnard L, Pearson J, Hasan R, O’Brien G. Presentation of depression in autism and Asperger syndrome: a review. Autism. 2006;10:103-116. 43 Spek AA, van Ham NC, Nyklicek I. Mindfulness-based therapy in adults with an autism spectrum disorder: a randomized controlled trial.
Chapter 3 Common psychiatric comorbidities and their assessment Stephanie H Ameis, Peter Szatmari Key Learning Objectives By the end of this chapter, readers will be able to identify: • recent evidence that indicates that a majority of children and adolescents with autism spectrum disorder (ASD) meet symptom criteria for at least one psychiatric disorder (particularly anxiety); • DSM-5 guidance for diagnosing comorbid ASD and a psychiatric condition; • limited range of validated tools available to help support clinicians in assessing for comorbid psychiatric disorders in ASD; • necessity of clinical judgment in combination with direct observation, careful history taking with caregivers, and collateral information to determine whether a comorbid psychiatric diagnosis should be made in individuals with ASD; • preliminary treatment studies that have demonstrated efficacy in treating other psychiatric symptoms (eg, attention deficit hyperactivity disorder [ADHD]) symptoms in individuals with ASD.
Nevertheless, atypical antipsychotic agents have a significant metabolic adverse event profile and their use should be guided carefully by evaluation of risk-to-benefit ratio. Summary of evidence: treatment for attention deficit hyperactivity symptom cluster Collectively, there is clear evidence to support the use of methylphenidate and, to some extent, atomoxetine, α2-agonists, and atypical antipsychotics as pharmacotherapy options for treating the ADHD symptom cluster in the context of ASD with moderate risk of adverse events.