Download Cancer and Pregnancy (Recent Results in Cancer Research) by A. Surbone, F. Peccatori, N. Pavlidis PDF

By A. Surbone, F. Peccatori, N. Pavlidis

This e-book is written by means of specialists with medical services on prognosis, therapy, and follow-up of ladies with melanoma while pregnant. It offers a finished evaluation of knowledge and an summary of mental, moral, and social features. Chapters tackle the analysis, therapy, and follow-up of girls with good or hematologic cancers. the security of next being pregnant and the upkeep or enhancement of fertility in girls present process melanoma remedy also are addressed.

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Additional info for Cancer and Pregnancy (Recent Results in Cancer Research)

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For patients who desire to continue the pregnancy, treatment is possible, but there is a limited number of options during the first weeks of gestation. In fact, chemotherapy is prohibited during the first trimester (Berry et al. 1999; Cardonick and Iacubucci 2004). Surgery is safe at any time (Duncan et al. 1986), but breast conservation performed during the first trimester is probably associated with an excessively long delay in postoperative radiotherapy. Therefore, in a patient at the first trimester who wants to continue the pregnancy and also wishes to conserve the breast all these issues have to be carefully discussed, and the patient has to be informed that a possible increased risk of local recurrence should be considered, even though this is difficult to quantify because of the lack of data.

Overall, the risk of teratogenesis following cancer treatment appears to be lower than is commonly estimated from animal data. First-trimester exposure to chemotherapy has been associated with 10%–20% risk of major malformations (Weisz et al. 2004). A review of 139 cases of first-trimester exposure to chemotherapy has demonstrated a 17% risk for malformations after single-agent exposure and 25% after exposure to combination chemotherapy (Doll et al. 1998). When folate antagonists were excluded, the incidence of fetal malformations with single-agent chemotherapy during the first trimester declined to 6%.

Obstet Gynecol Clin North Am 24: 591–599 Steege JF, Caldwell DS (1980) Renal agenesis after first trimester exposure to chlorambucil. South Med J 73: 1414–1415 Stentoft J, Nielsen JL, Hvidman LE (1994) All-trans retinoic acid in acute promyelocytic leukemia in late pregnancy. Leukemia 8: 1585–1588 Taylor G, Blom J (1980) Acute leukemia during pregnancy. South Med J 73: 1314–1315 Toledo TM, Harper RC, Moser RH (1971) Fetal effects during cyclophosphamide and irradiation therapy. Ann Intern Med 74: 87–91 Vantroyen B, Vanstraelen D (2002) Management of essential thrombocythemia during pregnancy with aspirin, interferon alpha-2a and no treatment.

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